The PathHunter® PD-L1 Ligand cell line is a stable, engineered cell line designed for use with PD-1 Checkpoint Signaling Cell Lines. When co-cultured, the PD-L1 expressed in this cell line will induce activity of PD-1 receptors, which may be assayed through SH2 domain protein recruitment. This product is a companion product designed to work with Immunoglobulin Superfamily Checkpoint Assays. The cell line included overexpresses PD-L1 cell surface ligand. When co-cultured with the corresponding Checkpoint Signaling Cell Line, the PD-L1 ligand binds to the checkpoint receptor, inducing receptor activity. This receptor activity leads to recruitment of the relevant SH2 domain protein to the checkpoint receptor inside the receptor cell line and production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.
IgSF (immune inhibitory Receptor ligand)
Programmed cell death 1 ligand 1, B7-H, B7H1, PDL1, PD-L1, hPD-L1, PDCD1L1, PDCD1LG1, CD274
Stable Cell Lines
Drug Discovery & Development
Store in vapor phase of liquid nitrogen.
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PathHunter® U2OS PD-L1 Ligand Cell Line
The PathHunter® U2OS PD-L1 Ligand Cell Line works with Checkpoint signaling cell lines to induce SH2 domain protein recruitment. This cell line ships as two vials of cryopreserved cells.
User Manuals & Protocols