The PathHunter® U2OS p53 Nuclear Translocation Cell Line is a stable, engineered cell line for use in studying drug candidates affecting the p53 DNA damage pathway. This cell line enables assessment of ligand (e.g. camptothecin) based pathway activation via detection of resulting p53 nuclear translocation. This product uses EFC technology. The included cell line overexpresses PL-tagged p53 and nuclear localized EA alongside untagged Keap1. Upon pathway activation, induced nuclear translocation of p53 leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.
Cellular tumor antigen p53, TP53, tumor protein p53
Stable Cell Lines
Drug Discovery & Development
Store in vapor phase of liquid nitrogen.
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PathHunter® U2OS p53 Nuclear Translocation Cell Line
The PathHunter® U2OS p53 Nuclear Translocation Cell Line measures p53 DNA damage pathway activation via nuclear translocation of p53. This cell line ships as two vials of cryopreserved cells.
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