The PathHunter® OX40 Checkpoint Signaling cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting signaling checkpoints. This cell line enables assessment of OX40 induced non-canonical NF-κB signaling via detection of NIK stabilization. This product uses EFC technology. The included cell line overexpresses ED-tagged NIK (NF-kappa-B Inducing Kinase) protein as well as untagged OX40 receptor. Upon activation of the receptor by its ligand or an antibody, NIK is stabilized, allowing detection of EFC signal when treated with exogenous EA. This stable modified cell line is provided as two vials of cryopreserved cells.
Tumor Necrosis Factor Receptor Superfamily Receptor
Tumor necrosis factor receptor superfamily, member 4
Stable Cell Lines
Drug Discovery & Development
Store in vapor phase of liquid nitrogen.
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PathHunter® U2OS OX40 Signaling Assay
The PathHunter® U2OS OX40 Signaling Assay measures OX40 signal by activation-induced stabilization of NIK. This cell line ships as two vials of cryopreserved cells.
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