PathHunter® U2OS mCD80 Ligand Cell Line

Background Information:

The PathHunter® U2OS mCD80 Ligand cell line is a stable, engineered cell line designed for use with mCD80 Checkpoint Signaling Cell Lines. When co-cultured, the mCD80 expressed in this cell line will induce activity of CD80 receptors, which may be assayed through SH2 domain protein recruitment. This product is a companion product designed to work with Immunoglobulin Superfamily Checkpoint Assays. The cell line included overexpresses mCD80 cell surface ligand. When co-cultured with the corresponding Checkpoint Signaling Cell Line, the mCD80 ligand binds to the checkpoint receptor, inducing receptor activity. This receptor activity leads to recruitment of the relevant SH2 domain protein to the checkpoint receptor inside the receptor cell line and production of EFC signal.
This stable engineered cell line is provided as two vials of cryopreserved cells. Please note this product expresses the mouse version of CD80.

Target Class:

Checkpoint Receptor

Family:

IgSF

Sub Family:

Immune Inhibitory Receptor Ligand

Protein Name:

CD80

Protein Aliases:

B-lymphocyte activation antigen B7

Accession Number:

NM_001359898

UniProt Number:

Q00609

Gene Name:

Cd80

Gene ID:

12519

Gene Aliases:

B7.1|B7-1

Target Species:

Mouse

Cell Background:

U2OS