PathHunter® U2OS IL6RA/IL6ST Dimerization Cell Line

The PathHunter® U2OS IL6RA/IL6ST Dimerization Cell Line measures ligand-induced dimerization of IL6RA/IL6ST . This cell line ships as two vials of cryopreserved cells.

Catalog #: 93-1045C3 Size: 2 vials
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Biological Information
Background Information:
The PathHunter® IL6RA/IL6ST Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. IL-6) induced dimerization of IL6RA/IL6ST receptors. This product uses EFC technology. The cell line included overexpresses IL6ST target protein fused to PK alongside IL6RA target protein fused to EA. Upon ligand-induced dimerization of IL6RA/IL6ST , detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:
Cytokine Receptor
Family:
IL-6 Receptor Family
Accession Number:
NM_000565.3
Target Name:
IL6RA/IL6ST
Target Aliases:
interleukin 6 receptor, CD126, IL-6R, IL-6R-alpha, IL-6RA, Il6r, GP130, CD130, CDW130, HIES4, HIES4A, HIES4B, IL-6RB, IMD94, STWS2, sGP130
Target Species:
Human
Cell Background:
U2OS
Usage
Product Type:
Stable Cell Lines
Application:
Drug Discovery & Development
Storage Conditions:
Store in vapor phase of liquid nitrogen.
Usage Disclaimer:
These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
Assay Information
Assay Type:
Functional
Assay Measures:
Dimerization
Detection Method:
Chemiluminescence
Clinical Relevance
Therapeutic Area:
Inflammation/Allergy
Additional Information
Brand:
PathHunter®

User Manuals & Protocols

70-303 PathHunter Dimerization Assay REV3 User Manual

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Datasheets

93-1045C3 Datasheet

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