PathHunter® U2OS IL4R/IL2RG Dimerization Cell Line

The PathHunter® U2OS IL4R/IL2RG Dimerization Cell Line measures ligand-induced dimerization of IL4R/IL2RG . This cell line ships as two vials of cryopreserved cells.

Catalog #: 93-0988C3 Size: 2 vials

Biological Information
Background Information:	The PathHunter® IL4R/IL2RG Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. IL-4) induced dimerization of IL4R/IL2RG receptors. This product uses EFC technology. The cell line included overexpresses IL4R target protein fused to PK alongside IL2RG target protein fused to EA. Upon ligand-induced dimerization of IL4R/IL2RG , detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:	Cytokine Receptor
Family:	IL-2 Receptor Family
Accession Number:	NM_000418.3
Target Name:	IL4R/IL2RG
Target Aliases:	Interleukin 4 receptorCD124IL-4RAAIL4R
Target Species:	Human
Cell Background:	U2OS

Usage
Product Type:	Stable Cell Lines
Application:	Drug Discovery & Development
Storage Conditions:	Short term (24 h): Store in vapor phase of liquid nitrogen.
Usage Disclaimer:	These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information
Assay Type:	Functional
Assay Measures:	Dimerization
Detection Method:	Chemiluminescence

Clinical Relevance
Therapeutic Area:	Inflammation/Allergy

Additional Information
Brand:	PathHunter®