PathHunter® U2OS IL27RA/IL6ST Dimerization Cell Line

The PathHunter® U2OS IL27RA/IL6ST Dimerization Cell Line measures ligand-induced dimerization of IL27RA/IL6ST . This cell line ships as two vials of cryopreserved cells.

Catalog #: 93-1119C3 Size: 2 vials

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Biological Information
Background Information:	The PathHunter® IL27RA/IL6ST Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. IL-27) induced dimerization of IL27RA/IL6ST receptors. This product uses EFC technology. The cell line included overexpresses IL6ST target protein fused to PK alongside IL27RA target protein fused to EA. Upon ligand-induced dimerization of IL27RA/IL6ST , detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:	Cytokine Receptor
Family:	IL-12 Receptor Family
Accession Number:	NM_004843.3
Target Name:	IL27RA/IL6ST
Target Aliases:	Interleukin 27 receptor, IL-27R, Interleukin 27 receptor subunit alpha, CRL1, IL-27RA, IL27R, TCCR, WSX1, zcytor1GP130, CD130, CDW130, HIES4, HIES4A, HIES4B, interleukin 6 receptor, IL-6R, IL-6RB, IMD94, STWS2, sGP130
Target Species:	Human
Cell Background:	U2OS

Usage
Product Type:	Stable Cell Lines
Application:	Drug Discovery & Development
Storage Conditions:	Store in vapor phase of liquid nitrogen.
Usage Disclaimer:	These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information
Assay Type:	Functional
Assay Measures:	Dimerization
Detection Method:	Chemiluminescence

Clinical Relevance
Therapeutic Area:	Inflammation/Allergy

Additional Information
Brand:	PathHunter®