PathHunter® U2OS IL1RL1/IL1RAP Dimerization Cell Line

The PathHunter® U2OS IL1RL1/IL1RAP Dimerization Cell Line measures ligand-induced dimerization of IL1RL1/IL1RAP . This cell line ships as two vials of cryopreserved cells.

Catalog #: 93-1067C3 Size: 2 vials
Inquire
Biological Information
Background Information:
The PathHunter® IL1RL1/IL1RAP Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. IL-33) induced dimerization of IL1RL1/IL1RAP receptors. This product uses EFC technology. The cell line included overexpresses IL1RL1 target protein fused to PK alongside IL1RAP target protein fused to EA. Upon ligand-induced dimerization of IL1RL1/IL1RAP , detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:
Cytokine Receptor
Family:
Immunoglobulin-like family of IL-1 Receptors
Accession Number:
NM_016232.4
Target Name:
IL1RL1/IL1RAP
Target Aliases:
interleukin 1 receptor, interleukin 1 receptor-like 1, IL33R, DER4, FIT-1, ST2, ST2L, ST2V, T1IL-1RAcP, IL1R3
Target Species:
Human
Cell Background:
U2OS
Usage
Product Type:
Stable Cell Lines
Application:
Drug Discovery & Development
Storage Conditions:
Store in vapor phase of liquid nitrogen.
Usage Disclaimer:
These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
Assay Information
Assay Type:
Functional
Assay Measures:
Dimerization
Detection Method:
Chemiluminescence
Clinical Relevance
Therapeutic Area:
Inflammation/Allergy
Additional Information
Brand:
PathHunter®

User Manuals & Protocols

70-303 PathHunter Dimerization Assay REV3 User Manual

View Document

Datasheets

93-1067C3 Datasheet

View Document
AssayComplete™ Cell Culture Kit-103
92-3103G
Kit

$397.00

AssayComplete™ Thawing Reagent T3
92-4103TR
100 mL

$249.00

PathHunter® Flash Detection Kit
93-0247
Inquire
AssayComplete™ Cell Plating 5 Reagent
93-0563R5A
100 mL

$339.00

AssayComplete™ Cell Detachment Reagent
92-0009
50 mL

$109.00

AssayComplete™ Freezing Reagent F3
92-5103FR
2 x 50 mL

$339.00