| Biological Information | |
|---|---|
| Background Information: | The PathHunter® IL1RL1/IL1RAP Dimerization Bioassay kit provides an easy-to-use cell-based assay to measure drug potency and detect neutralizing antibodies. This bioassay assesses ligand (e.g. IL-33) induced dimerization of IL1RL1/IL1RAP receptors. This product uses EFC technology. The cell line included overexpresses IL1RA target protein fused to EA alongside IL1RAP target protein fused to PK. Upon ligand-induced dimerization of IL1RL1/IL1RAP, detectable EFC signal is produced. Bioassay kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, control agonist, detection reagent, and assay plates. |
| Target Class: | Cytokine Receptor |
| Family: | Immunoglobulin-like family of IL-1 Receptors |
| Accession Number: | NM_016232.4 |
| Target Name: | IL1RL1/IL1RAP |
| Target Aliases: | IL1RL1- T1, ST2, DER4, ST2L, ST2V, FIT-1, IL33R/ IL1R3, C3orf13, IL-1RAcP, interleukin 1 receptor-like 1 |
| Target Species: | Human |
| Cell Background: | U2OS |
| Usage | |
| Product Type: | Bioassay Kits |
| Application: | Potency; Commercial Release & Stability |
| Kit Components: |  |
| Storage Conditions: | Store in vapor phase of liquid nitrogen. |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
| Assay Information | |
| Assay Type: | Functional |
| Assay Measures: | Dimerization |
| Detection Method: | Chemiluminescence |
| Clinical Relevance | |
| Therapeutic Area: | Inflammation/Allergy |
| Additional Information | |
| Brand: | PathHunter® |
PathHunter® U2OS IL1RL1/IL1RAP Bioassay Kit
The PathHunter® IL1RL1/IL1RAP Dimerization Bioassay kit provides an easy-to-use cell-based assay to measure drug potency and detect neutralizing antibodies. This bioassay assesses ligand (e.g. IL-33) induced dimerization of IL1RL1/IL1RAP receptors.
User Manuals & Protocols
70-360 PathHunter U2OS IL1RL1.IL1RAP Dimerization Bioassay Kit User Manual REV1
View DocumentDatasheets
93-1067Y3x Datasheet
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