Specifications
Documentation
Biological Information
Background Information:
The PathHunter® IL1RL1/IL1RAP Dimerization Bioassay kit provides an easy-to-use cell-based assay to measure drug potency and detect neutralizing antibodies. This bioassay assesses ligand (e.g. IL-33) induced dimerization of IL1RL1/IL1RAP receptors. This product uses EFC technology. The cell line included overexpresses IL1RA target protein fused to EA alongside IL1RAP target protein fused to PK. Upon ligand-induced dimerization of IL1RL1/IL1RAP, detectable EFC signal is produced. Bioassay kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, control agonist, detection reagent, and assay plates.
Target Class:
Cytokine Receptor
Family:
IL-1 Receptor
Protein Name:
IL1RL1
Accession Number:
NM_016232.4
UniProt Number:
Q01638
Gene Name:
IL1RL1
Gene ID:
9173
Gene Aliases:
DER4|ST2|T1
Target Species:
Human
Cell Background:
U2OS
Usage
Product Type:
Bioassay Kits
Application:
Potency, Commercial Release & Stability
Kit Components:
Storage Conditions:
Store in vapor phase of liquid nitrogen.
Usage disclaimer:
These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
Assay Information
Assay Type:
Cell Based
Assay Measures:
Dimerization
Detection Method:
Chemiluminescence
Clinical Relevance
Therapeutic Area:
Inflammation/Allergy
Additional Information
Brand:
PathHunter®