| Biological Information | |
|---|---|
| Background Information: | The PathHunter® IL1R1/IL1RAP Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. IL-1α) induced dimerization of IL1R1/IL1RAP receptors. This product uses EFC technology. The cell line included overexpresses IL1RAP target protein fused to PK alongside IL1R1 target protein fused to EA. Upon ligand-induced dimerization of IL1R1/IL1RAP , detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells. |
| Target Class: | Cytokine Receptor |
| Family: | Immunoglobulin-like family of IL-1 Receptors |
| Target Name: | IL1R1/ILRAP |
| Target Species: | Human |
| Cell Background: | U2OS |
| Usage | |
| Product Type: | Stable Cell Lines |
| Application: | Drug Discovery & Development |
| Storage Conditions: | Store in vapor phase of liquid nitrogen. |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
| Assay Information | |
| Assay Type: | Functional |
| Assay Measures: | Dimerization |
| Detection Method: | Chemiluminescence |
| Clinical Relevance | |
| Therapeutic Area: | Inflammation/Allergy |
| Additional Information | |
| Brand: | PathHunter® |
PathHunter® U2OS IL1R1/IL1RAP Dimerization Cell Line
The PathHunter® U2OS IL1R1/IL1RAP Dimerization Cell Line measures ligand-induced dimerization of IL1R1/IL1RAP . This cell line ships as two vials of cryopreserved cells.
User Manuals & Protocols
70-303 PathHunter Dimerization Assay REV3 User Manual
View DocumentDatasheets
93-1032C3 Datasheet
View Document