Biological Information

Background Information:

The PathHunter® IL1R1/IL1RAP Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. IL-1α) induced dimerization of IL1R1/IL1RAP receptors. This product uses EFC technology. The cell line included overexpresses IL1RAP target protein fused to PK alongside IL1R1 target protein fused to EA. Upon ligand-induced dimerization of IL1R1/IL1RAP , detectable EFC signal is produced.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Cytokine Receptor

Family:

IL-1 Receptor

Protein Name:

IL1R1

Protein Aliases:

IL-1RT-1|IL-1RT1|CD121 antigen-like family member A|Interleukin-1 receptor alpha|IL-1R-alpha|Interleukin-1 receptor type I|p80|CD antigen CD121a [Cleaved into: Interleukin-1 receptor type 1, membrane form|mIL-1R1|mIL-1RI; Interleukin-1 receptor type 1, soluble form|sIL-1R1|sIL-1RI]

Accession Number:

NM_000877.3

UniProt Number:

P14778

Gene Name:

IL1R1

Gene ID:

3554

Gene Aliases:

IL1R|IL1RA|IL1RT1

Target Species:

Human

Cell Background:

U2OS

Usage

Product Type:

Stable Cell Lines

Application:

Drug Discovery & Development

Storage Conditions:

Store in vapor phase of liquid nitrogen.

Usage disclaimer:

These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information

Assay Type:

Cell Based

Assay Measures:

Dimerization

Detection Method:

Chemiluminescence

Clinical Relevance

Therapeutic Area:

Inflammation/Allergy

Additional Information

Brand:

PathHunter®