PathHunter® U2OS IL10RA/IL10RB Dimerization Cell Line

The PathHunter® U2OS IL10RA/IL10RB Dimerization Cell Line measures ligand-induced dimerization of IL10RA/IL10RB . This cell line ships as two vials of cryopreserved cells.

Catalog #: 93-0985C3 Size: 2 vials
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Biological Information
Background Information:
The PathHunter® IL10RA/IL10RB Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. IL-10) induced dimerization of IL10RA/IL10RB receptors. This product uses EFC technology. The cell line included overexpresses IL10RA target protein fused to PK alongside IL10RB target protein fused to EA. Upon ligand-induced dimerization of IL10RA/IL10RB , detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:
Cytokine Receptor
Family:
Type II Cytokine Receptor
Accession Number:
NM_001558.3
Target Name:
IL10RA/IL10RB
Target Aliases:
IL-10 Receptor, Interleukin 10 receptor, IL-10R: CD210, CD210a, CDW210A, HIL-10R, IL-10R1, IL10R, CDW210B, CRF2-4, CRFB4, D21S58, D21S66, IBD25, IL-10R2, IL-10RB
Target Species:
Human
Cell Background:
U2OS
Usage
Product Type:
Stable Cell Lines
Application:
Drug Discovery & Development
Storage Conditions:
Store in vapor phase of liquid nitrogen.
Usage Disclaimer:
These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
Assay Information
Assay Type:
Functional
Assay Measures:
Dimerization
Detection Method:
Chemiluminescence
Clinical Relevance
Therapeutic Area:
Inflammation/Allergy
Additional Information
Brand:
PathHunter®

User Manuals & Protocols

70-303 PathHunter Dimerization Assay REV3 User Manual

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Datasheets

93-0985C3 Datasheet

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