Biological Information

Background Information:

The PathHunter® IFNRL1/IL10RB Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. IL-29) induced dimerization of IFNRL1/IL10RB receptors. This product uses EFC technology. The cell line included overexpresses IFNRL1 target protein fused to PK alongside IL10RB target protein fused to EA. Upon ligand-induced dimerization of IFNRL1/IL10RB , detectable EFC signal is produced.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Cytokine Receptor

Family:

IL-10 Receptor

Protein Name:

IFN-lambda R1

Protein Aliases:

IFN-lambda-R1|Cytokine receptor class-II member 12|Cytokine receptor family 2 member 12|CRF2-12|Interleukin-28 receptor subunit alpha|IL-28 receptor subunit alpha|IL-28R-alpha|IL-28RA|Likely interleukin or cytokine receptor 2|LICR2

Accession Number:

NM_170743.3

UniProt Number:

Q8IU57

Gene Name:

IFNLR1

Gene ID:

163702

Gene Aliases:

IL28RA|LICR2

Target Species:

Human

Cell Background:

U2OS

Usage

Product Type:

Stable Cell Lines

Application:

Drug Discovery & Development

Storage Conditions:

Store in vapor phase of liquid nitrogen.

Usage disclaimer:

These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information

Assay Type:

Cell Based

Assay Measures:

Dimerization

Detection Method:

Chemiluminescence

Clinical Relevance

Therapeutic Area:

Inflammation/Allergy

Additional Information

Brand:

PathHunter®