PathHunter® HVEM Ligand Cell Line (U2OS)

The PathHunter® HVEM Ligand Cell Line (U2OS) works with Checkpoint signaling cell lines to induce SH2 domain protein recruitment.

Catalog #: 93-1185C3 Size: 2 vials

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Biological Information
Background Information:	The PathHunter® HVEM Ligand Cell Line (U2OS) is a stable, engineered cell line designed for use with BTLA Checkpoint Signaling Cell Lines. When co-cultured, the HVEM expressed in this cell line will induce activity of BTLA receptors, which may be assayed through SH2 domain protein recruitment. This product is a companion product designed to work with Immunoglobulin Superfamily Checkpoint Assays. The cell line included overexpresses HVEM cell surface ligand. When co-cultured with the corresponding Checkpoint Signaling Cell Line, the HVEM ligand binds to the checkpoint receptor, inducing receptor activity. This receptor activity leads to recruitment of the relevant SH2 domain protein to the checkpoint receptor inside the receptor cell line and production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:	Checkpoint Receptor
Family:	Tumor Necrosis Factor Receptor Superfamily Receptor
Accession Number:	NM_003820.3
Target Aliases:	Tumor necrosis factor receptor superfamily member 14
Target Species:	Human
Cell Background:	U2OS

Usage
Product Type:	Stable Cell Lines
Application:	Drug Discovery & Development
Storage Conditions:	Store in vapor phase of liquid nitrogen.
Usage Disclaimer:	These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information
Assay Type:	Functional
Assay Measures:	Signaling

Clinical Relevance
Therapeutic Area:	Oncology/Immuno-Oncology

Additional Information
Brand:	PathHunter®