PathHunter® U2OS GHSR Bioassay Kit

Background Information:

The PathHunter® U2OS GHSR Bioassay kit provides a robust, highly sensitive, and easy-to-use functional cell based assay to measure drug potency and detect neutralizing antibodies. This bioassay assesses ligand based activation of GHSR GPCR via detection of β-arrestin recruitment. The included cells overexpress ProLink-tagged GHSR and EA-tagged β-Arrestin-2. Activation of GHSR stimulates the recruitment of β-Arrestin-2 and produces EFC signal. Bioassay kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, control agonist, detection reagent, and assay plates.

Target Class:

GPCR

Family:

Ghrelin

Sub Family:

Class A

Protein Name:

GHSR

Protein Aliases:

GH-releasing peptide receptor|GHRP|Ghrelin receptor

Accession Number:

NM_198407

UniProt Number:

Q92847

Gene Name:

GHSR

Gene ID:

2693

Target Species:

Human

Cell Background:

U2OS