Biological Information

Background Information:

The PathHunter® FGFR3/FGFR3 Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. FGF-18) induced dimerization of FGFR3/FGFR3 receptors. This product uses EFC technology. The cell line included overexpresses FGFR3 target protein fused to PK alongside FGFR3 target protein fused to EA. Upon ligand-induced dimerization of FGFR3/FGFR3 , detectable EFC signal is produced.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Kinase

Family:

RTK

Sub Family:

Protein Tyrosine

Protein Name:

FGFR3

Protein Aliases:

CD antigen CD333

Accession Number:

NM_000142.4

UniProt Number:

P22607

Gene Name:

FGFR3

Gene ID:

2261

Gene Aliases:

CEK2|JTK4|CD333

Target Species:

Human

Cell Background:

U2OS

Usage

Product Type:

Stable Cell Lines

Application:

Drug Discovery & Development

Storage Conditions:

Store in vapor phase of liquid nitrogen.

Usage disclaimer:

These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information

Assay Type:

Cell Based

Assay Measures:

Dimerization

Detection Method:

Chemiluminescence

Clinical Relevance

Therapeutic Area:

Oncology/Immuno-Oncology

Additional Information

Brand:

PathHunter®