PathHunter® U2OS EphA7 Functional Assay

Background Information:

The PathHunter® U2OS EphA7 Functional Assay provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting RTKs. This kit assesses RTK activation via detection of activated EphA7 dimerization-induced SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses PK-tagged EphA7 and an EA-tagged SH2 domain protein. Upon ligand-induced receptor activation, SH2-EA recruitment leads to production of EFC signal.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Kinase

Family:

RTK

Sub Family:

Protein Tyrosine

Protein Name:

EphA7

Protein Aliases:

EPH homology kinase 3|EHK-3|EPH-like kinase 11|EK11|hEK11

Accession Number:

NM_004440.3

UniProt Number:

Q15375

Gene Name:

EPHA7

Gene ID:

2045

Gene Aliases:

Hek11

Target Species:

Human

Cell Background:

U2OS