PathHunter® U2OS CSF2RB/CSF2RA Dimerization Cell Line

The PathHunter® U2OS CSF2RB/CSF2RA Dimerization Cell Line measures ligand-induced dimerization of CSF2RB/CSF2RA . This cell line ships as two vials of cryopreserved cells.

Catalog #: 93-1078C3 Size: 2 vials

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Biological Information
Background Information:	The PathHunter® CSF2RB/CSF2RA Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. GM-CSF) induced dimerization of CSF2RB/CSF2RA receptors. This product uses EFC technology. The cell line included overexpresses CSF2RB target protein fused to PK alongside CSF2RA target protein fused to EA. Upon ligand-induced dimerization of CSF2RB/CSF2RA , detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:	Cytokine Receptor
Family:	IL-3 Receptor Family
Accession Number:	NM_000395.2
Target Name:	CSF2RB/CSF2RA (GM-CSF Receptor beta/alpha)
Target Aliases:	CSF2RB, CD131, CDw131, IL3RB, IL5RB, SMDP5, betaGMR, CD116, CDw116, CSF2R, CSF2RAX, CSF2RAY, CSF2RX, CSF2RY, GM-CSF-R-alpha, GMCSFR, GMCSFR-alpha, GMR, GMR-alpha, SMDP4, alphaGMR
Target Species:	Human
Cell Background:	U2OS

Usage
Product Type:	Stable Cell Lines
Application:	Drug Discovery & Development
Storage Conditions:	Store in vapor phase of liquid nitrogen.
Usage Disclaimer:	These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information
Assay Type:	Functional
Assay Measures:	Dimerization
Detection Method:	Chemiluminescence

Additional Information
Brand:	PathHunter®