Biological Information

Background Information:

The PathHunter® CSF1R/CSF1R Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. M-CSF) induced dimerization of CSF1R/CSF1R receptors. This product uses EFC technology. The cell line included overexpresses CSF1R target protein fused to PK alongside CSF1R target protein fused to EA. Upon ligand-induced dimerization of CSF1R/CSF1R , detectable EFC signal is produced.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Kinase

Family:

RTK

Sub Family:

Protein Tyrosine

Protein Name:

Fms (CSFR)

Protein Aliases:

CSF-1-R|CSF-1R|M-CSF-R|Proto-oncogene c-Fms|CD antigen CD115

Accession Number:

NM_005211.3

UniProt Number:

P07333

Gene Name:

CSF1R

Gene ID:

1436

Gene Aliases:

C-FMS|CSFR|CD115

Target Species:

Human

Cell Background:

U2OS

Usage

Product Type:

Stable Cell Lines

Application:

Drug Discovery & Development

Storage Conditions:

Store in vapor phase of liquid nitrogen.

Usage disclaimer:

These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information

Assay Type:

Cell Based

Assay Measures:

Dimerization

Detection Method:

Chemiluminescence

Additional Information

Brand:

PathHunter®