The PathHunter® U2OS CDC25A Degradation Cell Line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting the cell cycle checkpoint pathway. This cell line enables detection of levels of CDC25a, allowing for assessment of CHK-1-activation-induced CDC25a degradation. This product uses EFC technology. The cell line included overexpresses CDC25a target protein fused to PL. EA is contained in the detection reagent. Upon pathway-activation-induced degradation of CDC25a EFC signal is lost. This stable modified cell line is provided as two vials of cryopreserved cells.
Cell division cycle 25 homolog A
Stable Cell Lines
Drug Discovery & Development
Short term (24 h): Store in vapor phase of liquid nitrogen.
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PathHunter® U2OS CDC25A Degradation Cell Line
User Manuals & Protocols