PathHunter® U2OS ARH Protein Interaction Cell Line

Background Information:

The PathHunter® ARH Protein Interaction cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting NHR activation and recruitment of cofactors. This cell line enables assessment of ligand (e.g. FICZ) based NHR activation via detection of SRCP (steroid receptor co-activator peptide) recruitment. This product uses EFC technology. The included cell line overexpresses PK-tagged ARH NHR and EA-tagged steroid receptor co-activator peptide (SRCP). Upon activation of ARH, induced interaction with SRCP leads to production of EFC signal.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

NHR

Family:

Aryl Hydrocarbon

Sub Family:

Non-Steroid

Protein Name:

AHR

Protein Aliases:

AhR|Class E basic helix-loop-helix protein 76|bHLHe76

Accession Number:

NM_001621.4

UniProt Number:

P35869

Gene Name:

AHR

Gene ID:

196

Gene Aliases:

bHLHe76

Target Species:

Human

Cell Background:

U2OS