PathHunter® U2OS ACVRL1/ACVR2B Dimerization Cell Line

Background Information:

The PathHunter® ACVRL1/ACVR2B Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. GDF2/BMP9) induced dimerization of ACVRL1/ACVR2B receptors. This product uses EFC technology. The cell line included overexpresses ACVRL1 target protein fused to PK alongside ACVR2B target protein fused to EA. Upon ligand-induced dimerization of ACVRL1/ACVR2B , detectable EFC signal is produced.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Kinase

Family:

RSTK

Sub Family:

Protein Ser/Thr

Protein Name:

ALK1

Protein Aliases:

Activin receptor-like kinase 1|ALK-1|TGF-B superfamily receptor type I|TSR-I

Accession Number:

NM_000020.0

UniProt Number:

P37023

Gene Name:

ACVRL1

Gene ID:

94

Gene Aliases:

HHT2|ALK1|HHT|ACVRLK1

Target Species:

Human

Cell Background:

U2OS