PathHunter® U2OS ACVR1/ACVR2 Dimerization Cell Line

The PathHunter® U2OS ACVR1/ACVR2 Dimerization Cell Line measures ligand-induced dimerization of ACVR1/ACVR2 . This cell line ships as two vials of cryopreserved cells.

Catalog #: 93-0906C3 Size: 2 vials
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Biological Information
Background Information:
The PathHunter® ACVR1/ACVR2 Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. [ligand]) induced dimerization of ACVR1/ACVR2 receptors. This product uses EFC technology. The cell line included overexpresses ACVR1/ACVR2 target protein fused to PK alongside TGFBR2 target protein fused to EA. Upon ligand-induced dimerization of ACVR1/ACVR2 , detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:
Kinase
Family:
Ser/Thr Kinase: Type I Receptor
Sub Family:
Protein Ser/Thr
Accession Number:
NM_001616
Target Name:
ACVR1/ACVR2
Target Aliases:
activin receptor, activin A receptor, activin A receptor type 2A, Activin A receptor type IIA, ACTRIA, ACVRLK2, ALK2, FOP, SKR1, TSRI, ACVR1, ACTRII, ACVR2
Target Species:
Human
Cell Background:
U2OS
Usage
Product Type:
Stable Cell Lines
Application:
Drug Discovery & Development
Storage Conditions:
Store in vapor phase of liquid nitrogen.
Usage Disclaimer:
These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
Assay Information
Assay Type:
Functional
Assay Measures:
Dimerization
Detection Method:
Chemiluminescence
Additional Information
Brand:
PathHunter®

User Manuals & Protocols

70-303 PathHunter Dimerization Assay REV3 User Manual

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Datasheets

93-0906C3

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