PathHunter® PD-1 Signaling Bioassay Kit

The PathHunter® PD-1 Signaling Bioassay Kit provides an easy-to-use cell based assay to measure drug potency and detect neutralizing antibodies. Upon activation of the receptor by its ligand (e.g. PD-L1, PD-L2) recruitment of SH2 domain protein leads to production of EFC signal

Catalog #: 93-1104Y19-00117

$2,994.00 – $9,978.00

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Biological Information
Background Information:
The PathHunter® PD-1 Signaling Bioassay Kit provides an easy-to-use cell based assay to measure drug potency and detect neutralizing antibodies. The included cell line overexpresses ProLink-tagged PD-1 target protein and EA-tagged SH2 domain protein. Upon activation of the receptor by its ligand (e.g. PD-L1, PD-L2) or an agonist antibody, recruitment of SH2 domain protein to the phosphorylated receptor tail leads to production of EFC signal. Bioassay kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, control agonist, detection reagent, and assay plates.
Target Class:
Checkpoint Receptor
Family:
IgSF (immune inhibitory Receptor)
Accession Number:
NM_005018.2
Target Name:
PD-1
Target Aliases:
PDCD1Programmed cell death protein 1PD1PD-1CD279SLEB2hPD-1hPD-lhSLE1
Target Species:
Human
Cell Background:
Jurkat
Usage
Product Type:
Bioassay Kits
Application:
Potency, Commercial Release & Stability
Kit Components:
Storage Conditions:
Short term (24 h): Store in vapor phase of liquid nitrogen.
Usage Disclaimer:
These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
Assay Information
Assay Type:
Functional
Assay Measures:
Signaling
Detection Method:
Chemiluminescence
Clinical Relevance
Therapeutic Area:
Oncology/Immuno-Oncology
Additional Information
Brand:
PathHunter®

User Manuals & Protocols

70-399 PathHunter PD-1 Signaling Bioassay Kit User Manual REV1

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Datasheets

93-1104Y19x Datasheet

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