PathHunter® Panitumumab Bioassay Kit

Background Information:

The PathHunter® Panitumumab Bioassay kit provides an easy-to-use cell based assay to measure drug potency and detect neutralizing antibodies. This bioassay assesses EGF-induced dimerization of ErbB2 and EGFR receptors. This product uses EFC technology. The included cells overexpress ErbB2 target protein fused to PK alongside EGFR target protein fused to EA. Upon ligand-induced dimerization of ErbB2 and EGFR, detectable EFC signal is produced. This assay has been optimized and qualified with ‎Vectibix® (not supplied in the bioassay kit). ‎Vectibix® is a registered trademark of Amgen Inc. Bioassay kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, control agonist, detection reagent, and assay plates.

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Target Class:

Kinase

Family:

RTK

Sub Family:

Protein Tyrosine

Protein Name:

EGFR

Protein Aliases:

erythroblastic leukemia viral (v-erb-b) oncogene homolog (avian)|erb-b2 receptor tyrosine kinase 1

Accession Number:

NM_005228.3

UniProt Number:

P00533

Gene Name:

EGFR

Gene ID:

1956

Gene Aliases:

ERBB1

Target Species:

Human

Cell Background:

U2OS