PathHunter® IL-17A/IL-17F Bioassay Kit (Dimerization)

The PathHunter® IL-17A/IL-17F Bioassay Kit (Dimerization) provides an easy-to-use cell based assay to measure drug potency and detect neutralizing antibodies. This bioassay assesses ligand (e.g. IL-17) induced dimerization of IL-17A/IL-17F receptors

Catalog #: 93-0999Y3-00053

$1,989.00 – $8,979.00

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Biological Information
Background Information:
The PathHunter® IL-17A/IL-17F Bioassay Kit (Dimerization) provides an easy-to-use cell based assay to measure drug potency and detect neutralizing antibodies. This bioassay assesses ligand (e.g. IL-17) induced dimerization of IL-17A/IL-17F receptors. This product uses EFC technology. The cell line included overexpresses IL-17F receptor target protein fused to PK alongside IL17A receptor target protein fused to EA. Upon ligand-induced dimerization of IL-17A/IL-17F receptors, detectable EFC signal is produced. Bioassay kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, control agonist, detection reagent, and assay plates.
Target Class:
Cytokine Receptor
Family:
IL-17 Receptor Family
Accession Number:
NM_014339
Target Name:
IL17RA/IL17RC
Target Aliases:
IL-17R, IL-17 Receptor, IL17 Receptor, Interleukin 17 receptor A, CTLA-8, CTLA8, IL-17, IL-17A, IL17, ILA17
Target Species:
Human
Cell Background:
U2OS
Usage
Product Type:
Bioassay Kits
Application:
Potency; Commercial Release & Stability
Kit Components:
Storage Conditions:
Store in vapor phase of liquid nitrogen.
Usage Disclaimer:
These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
Assay Information
Assay Type:
Functional
Assay Measures:
Dimerization
Detection Method:
Chemiluminescence
Clinical Relevance
Therapeutic Area:
Inflammation/Allergy
Additional Information
Brand:
PathHunter®

User Manuals & Protocols

70-402_PathHunter IL-17 Bioassay kit (Dimerization) User Manual_Rev1

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Datasheets

93-0999Y3x Datasheet

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