PathHunter® HEK 293 KDR/KDR Dimerization Cell Line

Background Information:

The PathHunter® KDR/KDR Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. VEGF-121) induced dimerization of KDR/KDR receptors. This product uses EFC technology. The cell line included overexpresses KDR target protein fused to PK alongside KDR target protein fused to EA. Upon ligand-induced dimerization of KDR/KDR , detectable EFC signal is produced.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Kinase

Family:

RTK

Sub Family:

Protein Tyrosine

Protein Name:

KDR (VEGFR2)

Protein Aliases:

vascular endothelial growth factor receptor 2|fetal liver kinase 1

Accession Number:

NM_002253.2

UniProt Number:

P35968

Gene Name:

KDR

Gene ID:

3791

Gene Aliases:

FLK1|VEGFR|VEGFR2|CD309

Target Species:

Human

Cell Background:

HEK293