PathHunter® HEK 293 IL3RA/CD131 Dimerization Cell Line

The PathHunter® HEK 293 IL3RA/CD131 Dimerization Cell Line measures ligand-induced dimerization of IL3RA/CD131 . This cell line ships as two vials of cryopreserved cells.

Catalog #: 93-0969C1 Size: 2 vials

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Biological Information
Background Information:	The PathHunter® IL3RA/CD131 Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. IL-3) induced dimerization of IL3RA/CD131 receptors. This product uses EFC technology. The cell line included overexpresses IL3RA target protein fused to PK alongside CD131 target protein fused to EA. Upon ligand-induced dimerization of IL3RA/CD131 , detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:	Cytokine Receptor
Family:	IL-3 Receptor Family
Accession Number:	NM_002183.2
Target Name:	IL3RA/CD131
Target Aliases:	Interleukin 3 receptor, Interleukin-3 receptor alpha, CD123, IL-3R-alpha, IL3RY, IL3RX, IL3RY, hIL-3Ra, IL3RA, CSF2RB, CD131, CDw131, IL3RB, IL5RB, SMDP5, betaGMR
Target Species:	Human
Cell Background:	HEK293

Usage
Product Type:	Stable Cell Lines
Application:	Drug Discovery & Development
Storage Conditions:	Store in vapor phase of liquid nitrogen.
Usage Disclaimer:	These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information
Assay Type:	Functional
Assay Measures:	Dimerization
Detection Method:	Chemiluminescence

Clinical Relevance
Therapeutic Area:	Inflammation/Allergy

Additional Information
Brand:	PathHunter®