PathHunter® HEK 293 IFNAR1/IFNAR2 Dimerization Cell Line

Background Information:

The PathHunter® IFNAR1/IFNAR2 Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. IFN-beta) induced dimerization of IFNAR1/IFNAR2 receptors. This product uses EFC technology. The cell line included overexpresses IFNAR2 target protein fused to PK alongside IFNAR1 target protein fused to EA. Upon ligand-induced dimerization of IFNAR1/IFNAR2 , detectable EFC signal is produced.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Cytokine Receptor

Family:

Interferon Receptor

Protein Name:

IFN-alpha/beta R1

Protein Aliases:

IFN-alpha/beta receptor 1|Cytokine receptor class-II member 1|Cytokine receptor family 2 member 1|CRF2-1|Type I interferon receptor 1

Accession Number:

NM_000629.2

UniProt Number:

P17181

Gene Name:

IFNAR1

Gene ID:

3454

Gene Aliases:

IFNAR

Target Species:

Human

Cell Background:

HEK293