PathHunter® HEK 293 CD27 NF-kB Signaling Pathway Reporter Cell Line

Background Information:

The PathHunter® HEK 293 CD27 NF-kB Signaling Pathway Reporter Cell Line is a stable, engineered cell line that overexpresses CD27. It can be used in studying drug candidates (small molecules or biologics) affecting the NF-kB pathway. This cell line enables assessment of NF-kB pathway stimulation based on changes in the expression of a NF-Kb response element-driven reporter protein. This product uses EFC technology. The included cell line expresses PL-tagged reporter protein under the control of a NF-KB pathway-inducible transcriptional response element. Pathway activation induces expression of the PL-tagged protein, allowing detection of EFC signal upon addition of EA-containing detection reagent.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Signaling Pathway

Family:

Tumour Necrosis Factor (TNF)

Protein Name:

CD27

Protein Aliases:

CD27 antigen|T-cell activation antigen S152|TNFRSF7

Accession Number:

NM_001242.5; NM_003998.4

UniProt Number:

P26842

Gene Name:

CD27

Gene ID:

939

Gene Aliases:

S152|Tp55

Target Species:

Human

Cell Background:

HEK293