PathHunter® eXpress TIM3/TIM3 Dimerization Assay

Background Information:

The PathHunter® TIM3/TIM3 Dimerization eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This kit assesses ligand induced dimerization of TIM3/TIM3 receptors. This product uses EFC technology. The cells included overexpress TIM3 target protein fused to PK alongside TIM3 target protein fused to EA. Upon ligand-induced dimerization of TIM3/TIM3, detectable EFC signal is produced. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates.

Target Class:

Checkpoint Receptor

Protein Name:

TIM3

Protein Aliases:

T-cell immunoglobulin and mucin domain-containing protein 3|TIMD-3|T-cell immunoglobulin mucin receptor 3|TIM-3|T-cell membrane protein 3|CD antigen CD366

Accession Number:

NM_032782.4

UniProt Number:

Q8TDQ0

Gene Name:

HAVCR2

Gene ID:

84868

Gene Aliases:

TIM3|TIMD3

Target Species:

Human

Cell Background:

U2OS