Biological Information
Background Information:
The PathHunter® TGFBR1/ACVR2B Dimerization eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This kit assesses ligand (e.g. GDF-11) induced dimerization of TGFBR1/ACVR2B receptors. This product uses EFC technology. The cells included overexpress ACVR2B target protein fused to PK alongside TGFBR1 target protein fused to EA. Upon ligand-induced dimerization of TGFBR1/ACVR2B, detectable EFC signal is produced. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates.
Target Class:
Kinase
Family:
TKL
Sub Family:
Protein Ser/Thr
Protein Name:
TGFBR1
Protein Aliases:
activin A receptor type II-like kinase, 53kDa
Accession Number:
NM_004612
UniProt Number:
P36897
Gene Name:
TGFBR1
Gene ID:
7046
Gene Aliases:
ALK-5|ACVRLK4|ALK5|SKR4
Target Species:
Human
Cell Background:
U2OS
Usage
Product Type:
eXpress Assay Kits
Application:
Drug Discovery & Development
Storage Conditions:
Store in vapor phase of liquid nitrogen.
Usage disclaimer:
Ready-to-use eXpress assay kits are intended for in vitro research purposes only. These kits are not suitable for lot release applications. Refer to the ready-to-use bioassay kit format for potency testing in lot release for biologic therapeutics. These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discover
Assay Information
Assay Type:
Cell Based
Assay Measures:
Dimerization
Detection Method:
Chemiluminescence
Additional Information
Brand:
PathHunter®