PathHunter® eXpress rHTR2C U2OS β-Arrestin GPCR Assay

The PathHunter® eXpress rHTR2C U2OS β-Arrestin GPCR Assay measures rHTR2C (GPCR) activity via recruitment of β-Arrestin2. eXpress kits contain all assay materials: cells, reagents, and plates.

Catalog #: 93-0915E3RCP0L


Biological Information
Background Information:
The PathHunter® rHTR2C eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. serotonin) based activation of rHTR2C GPCR activity via detection of β-arrestin recruitment. This product uses EFC technology. The cells included overexpress PK-tagged rHTR2C and EA-tagged β-Arrestin-2. Activation of rHTR2C stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. Please note that this product expresses the Rat version of this protein.
Target Class:
5-Hydroxytryptamine Receptors (Serotonin)
Accession Number:
Target Name:
HTR2C (5-HT2C receptor)
Target Aliases:
5-hydroxytryptamine receptor 2C, 5-HT1C, 5-HT2C, 5-HTR2C, 5HTR2C, HTR1C
Target Species:
Cell Background:
Product Type:
eXpress Assay Kits
Drug Discovery & Development
Storage Conditions:
Store in vapor phase of liquid nitrogen.
Usage Disclaimer:
Ready-to-use eXpress assay kits are intended for in vitro research purposes only. These kits are not suitable for lot release applications. Refer to the ready-to-use bioassay kit format for potency testing in lot release for biologic therapeutics. These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
Assay Information
Assay Type:
β-Arrestin isoform:
Assay Measures:
β-Arrestin Recruitment
Detection Method:
Additional Information

User Manuals & Protocols

70-255 PathHunter B Arrestin eXpress GPCR Assay REV4 User Manual

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93-0915E3x Datasheet

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