Biological Information

Background Information:

The PathHunter® OSMRb/IL31RA Dimerization eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This kit assesses ligand (e.g. IL-31) induced dimerization of OSMRb/IL31RA receptors. This product uses EFC technology. The cells included overexpress OSMRb target protein fused to PK alongside IL31RA target protein fused to EA. Upon ligand-induced dimerization of OSMRb/IL31RA, detectable EFC signal is produced. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates.

Target Class:

Cytokine Receptor

Family:

IL-6 Receptor

Protein Name:

IL31RA

Protein Aliases:

IL-31R subunit alpha|IL-31R-alpha|IL-31RA|Cytokine receptor-like 3|GLM-R|hGLM-R|Gp130-like monocyte receptor|Gp130-like receptor|ZcytoR17

Accession Number:

NM_139017.5

UniProt Number:

Q8NI17

Gene Name:

IL31RA

Gene ID:

133396

Gene Aliases:

CRL3|GPL|UNQ6368/PRO21073/PRO21384

Target Species:

Human

Cell Background:

U2OS

Usage

Product Type:

eXpress Assay Kits

Application:

Drug Discovery & Development

Storage Conditions:

Store in vapor phase of liquid nitrogen.

Usage disclaimer:

Ready-to-use eXpress assay kits are intended for in vitro research purposes only. These kits are not suitable for lot release applications. Refer to the ready-to-use bioassay kit format for potency testing in lot release for biologic therapeutics. These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discover

Assay Information

Assay Type:

Cell Based

Assay Measures:

Dimerization

Detection Method:

Chemiluminescence

Clinical Relevance

Therapeutic Area:

Inflammation/Allergy

Additional Information

Brand:

PathHunter®