Biological Information
Background Information:
The PathHunter® IL22RA1/IL10RB Dimerization eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This kit assesses ligand (e.g. IL-22) induced dimerization of IL22RA1/IL10RB receptors. This product uses EFC technology. The cells included overexpress IL22RA1 target protein fused to PK alongside IL10RB target protein fused to EA. Upon ligand-induced dimerization of IL22RA1/IL10RB, detectable EFC signal is produced. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates.
Target Class:
Cytokine Receptor
Family:
IL-10 Receptor
Protein Name:
IL22RA1
Protein Aliases:
IL-22R-alpha-1|IL-22RA1|Cytokine receptor class-II member 9|Cytokine receptor family 2 member 9|CRF2-9|ZcytoR11
Accession Number:
NM_021258.3
UniProt Number:
Q8N6P7
Gene Name:
IL22RA1
Gene ID:
58985
Gene Aliases:
IL22R
Target Species:
Human
Cell Background:
HEK293
Usage
Product Type:
eXpress Assay Kits
Application:
Drug Discovery & Development
Storage Conditions:
Store in vapor phase of liquid nitrogen.
Usage disclaimer:
Ready-to-use eXpress assay kits are intended for in vitro research purposes only. These kits are not suitable for lot release applications. Refer to the ready-to-use bioassay kit format for potency testing in lot release for biologic therapeutics. These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discover
Assay Information
Assay Type:
Cell Based
Assay Measures:
Dimerization
Detection Method:
Chemiluminescence
Clinical Relevance
Therapeutic Area:
Inflammation/Allergy
Additional Information
Brand:
PathHunter®