Biological Information
Background Information:
The PathHunter® IL18R1/IL18RAP Dimerization eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This kit assesses ligand (e.g. IL-18) induced dimerization of IL18R1/IL18RAP receptors. This product uses EFC technology. The cells included overexpress IL18R1 target protein fused to PK alongside IL18RAP target protein fused to EA. Upon ligand-induced dimerization of IL18R1/IL18RAP, detectable EFC signal is produced. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates.
Target Class:
Cytokine Receptor
Family:
IL-1 Receptor
Protein Name:
IL18R1
Protein Aliases:
IL-18R1|CD218 antigen-like family member A|CDw218a|IL1 receptor-related protein|IL-1Rrp|IL1R-rp|Interleukin-18 receptor alpha|IL-18R-alpha|IL-18Ralpha|CD antigen CD218a
Accession Number:
NM_003855.3
UniProt Number:
Q13478
Gene Name:
IL18R1
Gene ID:
8809
Gene Aliases:
IL1RRP
Target Species:
Human
Cell Background:
U2OS
Usage
Product Type:
eXpress Assay Kits
Application:
Drug Discovery & Development
Storage Conditions:
Store in vapor phase of liquid nitrogen.
Usage disclaimer:
Ready-to-use eXpress assay kits are intended for in vitro research purposes only. These kits are not suitable for lot release applications. Refer to the ready-to-use bioassay kit format for potency testing in lot release for biologic therapeutics. These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discover
Assay Information
Assay Type:
Cell Based
Assay Measures:
Dimerization
Detection Method:
Chemiluminescence
Clinical Relevance
Therapeutic Area:
Inflammation/Allergy
Additional Information
Brand:
PathHunter®