PathHunter® eXpress IL12RB1/IL12RB2 Dimerization Assay

The PathHunter® eXpress IL12RB1/IL12RB2 Dimerization Assay measures ligand-induced dimerization of IL12RB1/IL12RB2. eXpress kits contain all assay materials: cells, reagents, and plates.

Catalog #: 93-1041E3CP0L


Biological Information
Background Information:
The PathHunter® IL12RB1/IL12RB2 Dimerization eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This kit assesses ligand (e.g. IL-12) induced dimerization of IL12RB1/IL12RB2 receptors. This product uses EFC technology. The cells included overexpress IL12RB2 target protein fused to PK alongside IL12RB1 target protein fused to EA. Upon ligand-induced dimerization of IL12RB1/IL12RB2, detectable EFC signal is produced. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates.
Target Class:
Cytokine Receptor
IL-12 Receptor Family
Accession Number:
Target Name:
Target Aliases:
IL-12R, IL12R, IL-12 Receptor, Interleukin 12 receptor, beta 1, CD212, IL-12R-BETA1, IL12RB, IMD30
Target Species:
Cell Background:
Product Type:
eXpress Assay Kits
Drug Discovery & Development
Storage Conditions:
Store in vapor phase of liquid nitrogen.
Usage Disclaimer:
Ready-to-use eXpress assay kits are intended for in vitro research purposes only. These kits are not suitable for lot release applications. Refer to the ready-to-use bioassay kit format for potency testing in lot release for biologic therapeutics. These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
Assay Information
Assay Type:
Assay Measures:
Detection Method:
Clinical Relevance
Therapeutic Area:
Additional Information

User Manuals & Protocols

70-301 PathHunter eXpress Dimerization Assay Kit REV3 User Manual

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93-1041E3x Datasheet

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