PathHunter® eXpress IFNRL1/IL10RB Dimerization Assay

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The PathHunter® eXpress IFNRL1/IL10RB Dimerization Assay measures ligand-induced dimerization of IFNRL1/IL10RB. eXpress kits contain all assay materials: cells, reagents, and plates.

Catalog #: 93-0993E3CP5L

$2,279.00 – $7,479.00

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Biological Information
Background Information:
The PathHunter® IFNRL1/IL10RB Dimerization eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This kit assesses ligand (e.g. IL-29) induced dimerization of IFNRL1/IL10RB receptors. This product uses EFC technology. The cells included overexpress IFNRL1 target protein fused to PK alongside IL10RB target protein fused to EA. Upon ligand-induced dimerization of IFNRL1/IL10RB, detectable EFC signal is produced. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates.
Target Class:
Cytokine Receptor
Family:
Interferon Receptor Family; IL-10 Receptor Family
Accession Number:
NM_170743.3
Target Name:
IFNRL1/IL10RB
Target Aliases:
type III IFNinterferonlambda receptor 1CRF2/12IFNLRIL-28R1IL28RALICR2
Target Species:
Human
Cell Background:
U2OS
Usage
Product Type:
eXpress Assay Kits
Application:
Drug Discovery & Development
Storage Conditions:
Short term (24 h): Store in vapor phase of liquid nitrogen.
Usage Disclaimer:
These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
Assay Information
Assay Type:
Functional
Assay Measures:
Dimerization
Detection Method:
Chemiluminescence
Clinical Relevance
Therapeutic Area:
Inflammation/Allergy
Additional Information
Brand:
PathHunter®

User Manuals & Protocols

70-301 PathHunter eXpress Dimerization Assay Kit REV3 User Manual

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Datasheets

93-0993E3x Datasheet

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