The PathHunter® eXpress CDC25A Degradation Assay provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting the cell cycle checkpoint pathway. This kit enables detection of levels of CDC25a, allowing for assessment of CHK-1-activation-induced CDC25a degradation. This product uses EFC technology. The cells included overexpress CDC25a target protein fused to PL. EA is contained in the detection reagent. Upon pathway-activation-induced degradation of CDC25a EFC signal is lost. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates.
Cell division cycle 25 homolog A
eXpress Assay Kits
Drug Discovery & Development
Short term (24 h): Store in vapor phase of liquid nitrogen.
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PathHunter® eXpress CDC25A Degradation Assay
The PathHunter® eXpress CDC25A Degradation Assay measures pathway activation-induced degradation of CDC25A target protein. eXpress kits contain all assay materials: cells, reagents, and plates.