PathHunter® eXpress BMPR1A/BMPR2 Dimerization Assay

Background Information:

The PathHunter® BMPR1A/BMPR2 Dimerization eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This kit assesses ligand (e.g. BMP-4) induced dimerization of BMPR1A/BMPR2 receptors. This product uses EFC technology. The cells included overexpress BMPR2 target protein fused to PK alongside BMPR1A target protein fused to EA. Upon ligand-induced dimerization of BMPR1A/BMPR2, detectable EFC signal is produced. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates.

Target Class:

Kinase

Family:

RSTK

Sub Family:

Protein Ser/Thr

Protein Name:

ALK3

Protein Aliases:

BMPR-1A|Activin receptor-like kinase 3|ALK-3|Serine/threonine-protein kinase receptor R5|SKR5|CD antigen CD292

Accession Number:

NM_004329.2

UniProt Number:

P36894

Gene Name:

BMPR1A

Gene ID:

657

Gene Aliases:

ALK3|CD292|ACVRLK3

Target Species:

Human

Cell Background:

U2OS