PathHunter® eXpress ACVR1B/BMPR2 Dimerization Assay

Background Information:

The PathHunter® ACVR1B/BMPR2 Dimerization eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This kit assesses ligand (e.g. activin A) induced dimerization of ACVR1B/BMPR2 receptors. This product uses EFC technology. The cells included overexpress ACVR1B target protein fused to PK alongside BMPR2 target protein fused to EA. Upon ligand-induced dimerization of ACVR1B/BMPR2, detectable EFC signal is produced. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates.

Target Class:

Kinase

Family:

RSTK

Sub Family:

Protein Ser/Thr

Protein Name:

ALK4

Protein Aliases:

Activin receptor type IB|ACTR-IB|Activin receptor-like kinase 4|ALK-4|Serine/threonine-protein kinase receptor R2|SKR2

Accession Number:

NM_004302.4

UniProt Number:

P36896

Gene Name:

ACVR1B

Gene ID:

91

Gene Aliases:

ALK4|SKR2|ActRIB|ACVRLK4

Target Species:

Human

Cell Background:

U2OS