PathHunter® CHO-K1 OXTR β-Arrestin Cell Line

The PathHunter® CHO-K1 OXTR β-Arrestin Cell Line measures OXTR (GPCR) activity via recruitment of β-Arrestin2. This cell line ships as two vials of cryopreserved cells.

Catalog #: 93-0261C2 Size: 2 vials
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Biological Information
Background Information:
The PathHunter® OXTR cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. oxytocin) based activation of OXTR GPCR activity via detection of β-arrestin recruitment. This product uses EFC technology. The included cell line overexpresses PK-tagged OXTR and EA-tagged β-Arrestin 2. Activation of OXTR stimulates the recruitment of β-Arrestin 2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:
GPCR
Family:
Vasopressin & Oxytocin Receptors
Sub Family:
Class A
Coupling:
Gq
Accession Number:
AY389507
Target Name:
OXTR
Target Aliases:
Oxytocin recepter, OT-R, OTR
Target Species:
Human
Cell Background:
CHO-K1
Usage
Product Type:
Stable Cell Lines
Application:
Drug Discovery & Development
Storage Conditions:
Store in vapor phase of liquid nitrogen.
Usage Disclaimer:
These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
Assay Information
Assay Type:
Functional
β-Arrestin isoform:
β-Arrestin-2
Assay Measures:
β-Arrestin Recruitment
Detection Method:
Chemiluminescence
Additional Information
Brand:
PathHunter®

User Manuals & Protocols

70-247 PathHunter Beta-Arrestin Assay for GPCR Cell Lines REV5 User Manual

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Datasheets

93-0261C2 Datasheet

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