PathHunter® CHO-K1 NPR1 Functional Assay

The PathHunter® CHO-K1 NPR1 Functional Assay measures NPR1 pathway activation via increase in cGMP levels. This cell line ships as two vials of cryopreserved cells.

Catalog #: 93-0804C2 Size: 2 vials

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Biological Information
Background Information:	The PathHunter® CHO-K1 NPR1 Functional Assay is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting NPR1. This cell line enables assessment of ligand (e.g. ANP) based stimulation of receptor activity via detection of resulting increases in the levels of intracellular cGMP. This product uses EFC technology. The included cell line overexpresses untagged NPR1 Upon activation of the pathway, the increase in levels of intracellular cGMP leads to production of increased EFC signal when the cGMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:	Signaling Pathway
Family:	Guanylate Cyclase A
Sub Family:	Cyclic Nucleotide Signaling
Accession Number:	NM_000906.3
Target Name:	NPR1
Target Aliases:	Natriuretic peptide receptor A
Target Species:	Human
Cell Background:	CHO-K1

Usage
Product Type:	Stable Cell Lines
Application:	Drug Discovery & Development
Storage Conditions:	Store in vapor phase of liquid nitrogen.
Usage Disclaimer:	These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information
Assay Type:	Functional
Assay Measures:	cGMP Detection
Detection Method:	Chemiluminescence

Additional Information
Brand:	PathHunter®