PathHunter® CHO-K1 mGLP1R β-Arrestin-1 Cell Line

The PathHunter® CHO-K1 mGLP1R β-Arrestin-1 Cell Line measures MGLP1R (GPCR) activity via recruitment of β-Arrestin-1. This cell line ships as two vials of cryopreserved cells. Mouse protein.

Catalog #: 93-0974C2 Size: 2 vials
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Biological Information
Background Information:
The PathHunter® mGLP1R (ARR1) cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. exendin-4) based activation of mGLP1R GPCR activity via detection of β-arrestin recruitment. This product uses EFC technology. The included cell line overexpresses PK-tagged mGLP1R and EA-tagged β-Arrestin-1. Activation of mGLP1R stimulates the recruitment of β-Arrestin-1 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the Mouse version of this protein.
Target Class:
GPCR
Family:
Glucagon Receptor Family
Coupling:
Gs
Accession Number:
NM_021332
Target Name:
GLP1R
Target Aliases:
Glucagon-like peptide receptor 1, GLP-1R, GLP1Rc
Target Species:
Mouse
Cell Background:
CHO-K1
Usage
Product Type:
Stable Cell Lines
Application:
Drug Discovery & Development
Storage Conditions:
Store in vapor phase of liquid nitrogen.
Usage Disclaimer:
These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
Assay Information
Assay Type:
Functional
β-Arrestin isoform:
β-Arrestin-1
Assay Measures:
β-Arrestin Recruitment
Detection Method:
Chemiluminescence
Clinical Relevance
Therapeutic Area:
Metabolic Diseases
Additional Information
Brand:
PathHunter®

User Manuals & Protocols

70-247 PathHunter Beta-Arrestin Assay for GPCR Cell Lines REV5 User Manual

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Datasheets

93-0974C2 Datasheet

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PathHunter® Detection Kit
93-0001
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