Biological Information

Background Information:

The PathHunter® mAVPR2 cell pool is a stable, engineered cell pool for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell pool enables assessment of ligand (e.g. vasopressin) based activation of mAVPR2 GPCR activity via detection of β-arrestin recruitment. The included cell pool overexpresses ProLink-tagged mAVPR2 and EA-tagged β-Arrestin-2. Activation of mAVPR2 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable cell pool is provided as two vials of cryopreserved cells. Please note that this product expresses the Mouse version of this protein.

Target Class:

GPCR

Family:

Vasopressin and Oxytocin

Sub Family:

Class A

Protein Name:

V2

Protein Aliases:

Nephrogenic diabetes insipidus

Accession Number:

NM_019404

UniProt Number:

Q3SWS4

Gene Name:

Avpr2

Gene ID:

12000

Gene Aliases:

ADHR|DIR|DIR3|V2R

Target Species:

Mouse

Cell Background:

CHO-K1

Usage

Product Type:

Cell Pool

Application:

Drug Discovery & Development

Storage Conditions:

Store in vapor phase of liquid nitrogen.

Usage disclaimer:

These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information

Assay Type:

Cell Based

Assay Measures:

β-Arrestin Recruitment

Detection Method:

Chemiluminescence

Additional Information

Brand:

PathHunter®