PathHunter® CHO-K1 mAVPR2 β-Arrestin Cell Pool

The PathHunter® mAVPR2 Cell Pool is a stable, engineered cell pool for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell pool enables assessment of ligand (e.g. vasopressin) based activation of mAVPR2 GPCR activity via detection of β-arrestin recruitment.

Catalog #: 93-0596P2 Size: 2 vials
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Biological Information
Background Information:
The PathHunter® mAVPR2 cell pool is a stable, engineered cell pool for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell pool enables assessment of ligand (e.g. vasopressin) based activation of mAVPR2 GPCR activity via detection of β-arrestin recruitment. The included cell pool overexpresses ProLink-tagged mAVPR2 and EA-tagged β-Arrestin-2. Activation of mAVPR2 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable cell pool is provided as two vials of cryopreserved cells. Please note that this product expresses the Mouse version of this protein.
Target Class:
GPCR
Family:
Vasopressin & Oxytocin Receptors
Accession Number:
NM_019404
Target Name:
AVPR2
Target Aliases:
DI1, DIR, ND1, V2R, ADHR, VPV2R, Vasopressin receptor 2
Target Species:
Mouse
Cell Background:
CHO-K1
Usage
Product Type:
Cell Pool
Application:
Drug Discovery & Development
Storage Conditions:
Store in vapor phase of liquid nitrogen.
Usage Disclaimer:
These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
Assay Information
Assay Type:
Functional
Assay Measures:
β-Arrestin Recruitment
Detection Method:
Chemiluminescence
Additional Information
Brand:
PathHunter®

User Manuals & Protocols

70-247 PathHunter Beta-Arrestin Assay for GPCR Cell Lines REV5 User Manual

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Datasheets

93-0596P2 Datasheet

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