Biological Information

Background Information:

The PathHunter® GPR107 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. nicotinic acid) based activation of GPR107 GPCR activity via detection of β-arrestin recruitment. This product uses EFC technology. The included cell line overexpresses PK-tagged GPR107 and EA-tagged β-Arrestin 2. Activation of GPR107 stimulates the recruitment of β-Arrestin 2 and produces EFC signal.
This stable engineered cell line is provided as two vials of cryopreserved cells. Orphan receptor with unknown ligand.

Target Class:

GPCR

Family:

Other 7TM proteins

Sub Family:

Orphan and other 7TM

Protein Name:

GPR107

Accession Number:

NM_020960

UniProt Number:

Q5VW38

Gene Name:

GPR107

Gene ID:

57720

Gene Aliases:

KIAA1624|LUSTR1

Target Species:

Human

Cell Background:

CHO-K1

Usage

Product Type:

Stable Cell Lines

Application:

Drug Discovery & Development

Storage Conditions:

Store in vapor phase of liquid nitrogen.

Usage disclaimer:

These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information

Assay Type:

Cell Based

β-Arrestin Isoform:

β-Arrestin-2

Assay Measures:

β-Arrestin Recruitment

Detection Method:

Chemiluminescence

Additional Information

Brand:

PathHunter®