PathHunter® CHO-K1 cyno GPR120 β-Arrestin Cell Line

The PathHunter® CHO-K1 cyno GPR120 β-Arrestin Cell Line measures GPR120 (GPCR) activity via recruitment of β-Arrestin2. This cell line ships as two vials of cryopreserved cells. Cyno protein.

Catalog #: 93-1029C2 Size: 2 vials
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Biological Information
Background Information:
The PathHunter® cyno GPR120 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. free fatty acids) based activation of GPR120 GPCR activity via detection of β-arrestin recruitment. This product uses EFC technology. The included cell line overexpresses PK-tagged cyno GPR120 and EA-tagged β-Arrestin 2. Activation of GPR120 stimulates the recruitment of β-Arrestin 2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the Cyno version of the protein.
Target Class:
GPCR
Family:
Chemokine Receptors
Accession Number:
NM_001287319
Target Name:
GPR120
Target Aliases:
G-protein coupled receptor 120
Target Species:
Cynomolgus Monkey
Cell Background:
CHO-K1
Usage
Product Type:
Stable Cell Lines
Application:
Drug Discovery & Development
Storage Conditions:
Store in vapor phase of liquid nitrogen.
Usage Disclaimer:
These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
Assay Information
Assay Type:
Functional
β-Arrestin isoform:
β-Arrestin-2
Assay Measures:
β-Arrestin Recruitment
Detection Method:
Chemiluminescence
Additional Information
Brand:
PathHunter®

User Manuals & Protocols

70-247 PathHunter Beta-Arrestin Assay for GPCR Cell Lines REV5 User Manual

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Datasheets

93-1029C2 Datasheet

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