PathHunter® CHO-K1 CNR1 Bioassay Kit

Background Information:

The PathHunter® CHO-K1 CNR1 Bioassay kit provides a robust, highly sensitive, and easy-to-use functional cell-based assay to measure drug potency and detect neutralizing antibodies. This bioassay assesses ligand (e.g. CP 55,940) based activation of CNR1 GPCR activity via detection of β-arrestin recruitment. The included cells overexpress ProLink-tagged CNR1 and EA-tagged β-Arrestin-2. Activation of CNR1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. Bioassay kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, control agonist, detection reagent, and assay plates

Target Class:

GPCR

Family:

Cannabinoid

Sub Family:

Class A

Protein Name:

CB1

Protein Aliases:

CB1|CANN6

Accession Number:

AY225225

UniProt Number:

P21554

Gene Name:

CNR1

Gene ID:

1268

Gene Aliases:

CB1K5|CB-R|CB1|CANN6|CB1A

Target Species:

Human

Cell Background:

CHO-K1