PathHunter® CHO-K1 CCR2 Bioassay Kit

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The PathHunter® CHO-K1 CCR2 Bioassay kit provides an easy-to-use cell based assay to measure drug potency and detect neutralizing antibodies. This bioassay assesses ligand (e.g. MCP-1/CCL2) based activation of CCR2 GPCR activity via detection of β-arrestin recruitment.

Catalog #: 93-0192Y2-00061

$1,989.00 – $8,979.00

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Biological Information
Background Information:
The PathHunter® CHO-K1 CCR2 Bioassay kit provides an easy-to-use cell based assay to measure drug potency and detect neutralizing antibodies. This bioassay assesses ligand (e.g. MCP-1/CCL2) based activation of CCR2 GPCR via detection of β-arrestin recruitment. The included cells overexpress ProLink-tagged CCR2 and EA-tagged β-Arrestin-2. Activation of CCR2 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. Bioassay kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, control agonist, detection reagent, and assay plates.
Target Class:
GPCR
Family:
Chemokine Receptors
Sub Family:
Class A
Accession Number:
NM_001123396
Target Name:
CCR2 (MIP-1R)
Target Aliases:
Chemokine (C-C motif) receptor 2, CC-CKR-2, CCR-2, CCR2A, CCR2B, CD192, CKR2, CKR2A, CKR2B, CMKBR2, MCP-1-R
Target Species:
Human
Cell Background:
CHO-K1
Usage
Product Type:
Bioassay Kits
Application:
Potency; Commercial Release & Stability
Kit Components:
Storage Conditions:
Store in vapor phase of liquid nitrogen.
Usage Disclaimer:
These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
Assay Information
Assay Type:
Functional
Assay Measures:
β-Arrestin Recruitment
Detection Method:
Chemiluminescence
Additional Information
Brand:
PathHunter®

User Manuals & Protocols

70-290 PathHunter GPCR Bioassay Kit REV11 User Manual

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Datasheets

93-0192Y2x Datasheet

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