PathHunter® CD200 Ligand Cell Line (Jurkat)

The PathHunter CD200 Ligand cell line is a stable, engineered cell line designed for use with CD200R Checkpoint Signaling Cell Lines. This stable cell line is provided as two vials of cryopreserved cells.

Catalog #: 93-1177C19 Size: 2 vials

Biological Information
Background Information:	The PathHunter CD200 Ligand cell line is a stable, engineered cell line designed for use with CD200R Checkpoint Signaling Cell Lines. When co-cultured, the CD200 expressed in this cell line will induce activity of CD200R receptors, which may be assayed through SH2 domain protein recruitment. This product is a companion product designed to work with Immunoglobulin Superfamily Checkpoint Assays. The cell line included overexpresses CD200 cell surface ligand. When co-cultured with the CD200R Checkpoint Signaling Cell Line, the CD200 ligand binds to the checkpoint receptor, inducing receptor activity. This receptor activity leads to recruitment of the relevant SH2 domain protein to the checkpoint receptor inside the receptor cell line and production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:	Checkpoint Receptor
Family:	IgSF (immune inhibitory Receptor ligand)
Sub Family:	CD Molecules
Accession Number:	NC_000003.12
Target Name:	CD200
Target Aliases:	MOX1, MOX2, MRC, OX-2
Target Species:	Human
Cell Background:	Jurkat

Usage
Product Type:	Stable Cell Lines
Application:	Drug Discovery & Development
Storage Conditions:	Short term (24 h): Store in vapor phase of liquid nitrogen.
Usage Disclaimer:	These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information
Assay Type:	Functional
Assay Measures:	Signaling
Detection Method:	Chemiluminescence

Clinical Relevance
Therapeutic Area:	Oncology/Immuno-Oncology

Additional Information
Brand:	PathHunter®